Miscarriage Research Today is a free monthly online journal that collates and summarizes the latest research about Miscarriage, including details on signs, symptoms, recurrent, pregnancy.

Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.

Yang H, Qiu L, Chen G, Ye Z, Lü C, Lin Q

Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

OBJECTIVE: To investigate the proportional changes of CD4(+)CD25(+) regulatory T cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion (URSA) and normal pregnant (NP) women. DESIGN: Prospective, case-control study. SETTING: Large public hospital in a major city in China. PATIENT(S): Twenty-five URSA patients and 34 normal, early pregnant, control women. INTERVENTION(S): Measurements of CD4(+)CD25(+) regulatory T cells in decidua and peripheral blood. MAIN OUTCOME MEASURE(S): The proportion of CD4(+)CD25(bright) regulatory T cells; the percentage of CD25(bright) cells in the CD4(+) T-cell population. RESULT(S): The proportions of CD4(+)CD25(bright) T cells in both decidua and peripheral blood in URSA patients were statistically significantly lower than those in control women. Meanwhile, the percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly lower in URSA patients than in control women. The percentage of CD25(bright) cells in the CD4(+) T-cell population in decidua was statistically significantly higher than that in peripheral blood in control women, whereas the difference was not significant in patients who have URSA. CONCLUSION(S): Human CD4(+)CD25(bright) T cells play a major role in tolerating conceptus antigens and therefore may contribute to the maintenance of pregnancy. The data suggest that CD4(+)CD25(+) regulatory T cells may be a novel target in URSA therapy.

Published 11 March 2008 in Fertil Steril, 89(3): 656-61.
Full-text of this article is available online (may require subscription).

Articles on Miscarriage published 11 March 2008:

Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman's syndrome.   Fertil Steril, 89(3): 715-22.

OBJECTIVE: To evaluate the outcome of hysteroscopic adhesiolysis in women with Asherman's syndrome. DESIGN: Retrospective clinical study. SETTING: Hysteroscopic center of Fuxing Hospital in Beijing, China. PATIENT(S): Patients with Asherman's syndrome who presented with a history of infertility or recurrent pregnancy loss were included in the study. INTERVENTION(S): The adhesions were divided hysteroscopically by electrode needle or loop under direct vision. A second look hysteroscopy was ... [Abstract] [Full-text]

Differences in characteristics among 1,000 women with endometriosis based on extent of disease.   Fertil Steril, 89(3): 538-45.

OBJECTIVE: To determine the relationship between disease severity and patient characteristics in endometriosis. DESIGN: Cross-sectional study of self-reported survey data. SETTING: Academic research setting. PATIENT(S): One thousand women in the Oxford Endometriosis Gene (OXEGENE) study. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Participants were assigned to one of two groups with predominantly revised AFS stage I-II (group I, n = 423) or III-IV disease (group II, n = 517). Their ... [Abstract] [Full-text]

Articles on Miscarriage published 3 March 2008:

Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study.   Am J Obstet Gynecol, 198(3): 279.e1-8.

OBJECTIVE: The objective of the study was to examine whether the risk of miscarriage is associated with caffeine consumption during pregnancy after controlling for pregnancy-related symptoms. STUDY DESIGN: This was a population-based prospective cohort study. RESULTS: An increasing dose of daily caffeine intake during pregnancy was associated with an increased risk of miscarriage, compared with no caffeine intake, with an adjusted hazard ratio (aHR) of 1.42 (95% confidence interval 0.93 to ... [Abstract] [Full-text]

Perceived risk of prenatal diagnostic procedure-related miscarriage and Down syndrome among pregnant women.   Am J Obstet Gynecol, 198(3): 333.e1-8.

OBJECTIVE: The objective of the study was to identify correlates of perceived risk of carrying a Down syndrome-affected fetus or experiencing a procedure-related miscarriage among a diverse group of pregnant women. STUDY DESIGN: We conducted a cross-sectional survey of 1081 English-, Spanish-, or Chinese-speaking women receiving prenatal care in the San Francisco Bay area. Perceived risk of procedure-related miscarriage or carrying a Down syndrome-affected fetus was assessed using a linear ... [Abstract] [Full-text]

Articles on Miscarriage published 27 February 2008:

Genetics of pregnancy loss.   Clin Obstet Gynecol, 51(1): 84-95.

Pregnancy loss is a common problem in reproductive-aged women. Although most cases of pregnancy loss are sporadic, some couples experience recurrent pregnancy loss, a challenging clinical dilemma. A variety of possible etiologies have been described for both sporadic and recurrent pregnancy loss. This review focuses on the genetic abnormalities that may contribute to this clinical problem and delineates strategies for genetic evaluation and clinical management in subsequent pregnancies. [Abstract] [Full-text]

Articles on Miscarriage published 20 February 2008:

Pregnancy, birth, and infant health outcomes from the National Smallpox Vaccine in Pregnancy Registry, 2003-2006.   Clin Infect Dis, 46: S221-6.

When the United States implemented civilian and military smallpox vaccination programs in 2003, the National Smallpox Vaccine in Pregnancy Registry was established to better evaluate outcomes after the inadvertent vaccination of pregnant women. Women were referred to the registry by vaccine administrators, health care providers, or state health departments or through self-referral. Registry professionals actively follow up with all enrolled women and collect data on pregnancy, birth, and infant ... [Abstract] [Full-text]

Articles on Miscarriage published 15 February 2008:

Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development.   Mol Cell Biol, 28(5): 1669-78.

ZO-1, ZO-2, and ZO-3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. Even though the zonula occludens (ZO) proteins are among the first TJ proteins to have been identified and have undergone extensive biochemical analysis, little is known about the physiological roles of individual ZO proteins in different tissues or during vertebrate development. Here, we show ... [Abstract] [Full-text]

Articles on Miscarriage published 14 February 2008:

Quality of life and acceptability of medical versus surgical management of early pregnancy failure.   BJOG, 115(4): 501-8.

OBJECTIVE: This study compares quality of life (QOL) and acceptability of medical versus surgical treatment of early pregnancy failure (EPF). DESIGN: A randomised clinical trial of treatment for EPF compared misoprostol vaginally versus vacuum aspiration (VA). SETTING: A multisite trial at four US Urban University Hospitals. POPULATION: A total of 652 women with an EPF were randomised to treatment. METHODS: Participants completed a daily symptom diary and a questionnaire 2 weeks after ... [Abstract] [Full-text]

© 2004-2008 Miscarriage Research Today. All Rights Reserved.